KHG fiteBac® Technology, a US biotech company, was founded by Dr. Kirk Kimmerling,
and built through the efforts of academia researchers throughout the world.

“Our mission is to utilize fiteBac® patented, antimicrobial technology through world-class research, to provide a healthier world”

KHG fiteBac® Technology’s antimicrobial platform chemistry has “built-in authority” generated by peer reviewed published research papers, and recognized by FDA.

This breakthrough technology has endless applications in the health-care field, resulting in the potential for saving millions of lives, and billions of dollars in health care costs.


Oral and Dental

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Petrochemical & Polymers

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Medical

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Paint & Coatings

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Drug Discovery

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Composites & Fibers

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Lead Molecule K-18: FDA 510(k) Clearance for Antimicrobial Dental Retainer

An antimicrobial and antifungal cationic quaternary ammonium methacryloxy silicate molecule (QAMS) has been synthesized by sol-gel reaction between a tetraalkoxysilane and two trialkoxysilanes. Containing a methacryloxy functional group and a long C-18 carbon chain, the QAMS molecule is soluble in MMA monomer and has been incorporated into PMMA orthodontic acrylic resin.

The QAMS-copolymerised acrylic resin demonstrated improved fracture toughness without adversely affecting flexural modulus and strength of the orthodontic acrylic. In previous in vitro studies, orthodontic acrylic resins containing 4–6% QAMS were found to possess in vitro immediate diffusional as well as contact-killing antimicrobial properties when tested with Streptococcus mutans, Actinomyces naeslundii and Candida albicans.  -Dr. Franklin P. Tay

Video Explanation:

Example of plaque biofilms containing mixed bacterial-fungal components.

(a) BacLightstained CLSM merged image showing the presence of live (green) fungal hyphae (open arrowhead) within the biovolume of a biofilm taken from a control disk of one subject (subject 21).

(b) The corresponding BacLightstained CLSM merged image showing the presence of dead (red) fungal hyphae killed by the QAMS-containing acrylic (open arrowhead) from an experimental disk of the same subject.

Antimicrobial fiteBac® Technology is available in compound or coating form.
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Adjusting the Molecule’s Central Core and Functional Groups allows for endless customizable & tailored chemistry.

KHG fiteBac® Technology


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UT Health
American Society for Microbiology
ClinicalTrials.gov
ELSEVIER
fiteBac
Georgia Health Services University
Japanese Society of Veterinary Science
Journal of Applied Microbiology
Journal of Endodontics
American Animal Hospital Assoc.
PLoS ONE
Polymer Chemistry
SCIENTIFIC REPORTS
University of Michigan
US EPA
  • Use of whole genome deep sequencing to define emerging minority variants in virus envelope genes in herpesvirus treated with novel antimicrobial K21
    ELSEVIER
    New antivirals are required to prevent rising antimicrobial resistance from replication inhibitors. The aim of this study was to analyse the range of emerging mutations in herpesvirus by whole genome deep sequencing. We tested human herpesvirus 6 treatment with novel antiviral K21, where evidence indicated distinct effects on virus envelope proteins.
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  • Quaternary ammonium based biomedical materials: State-of-the-art toxicological aspects and antimicrobial resistance
    ELSEVIER
    Microbial infections affect humans worldwide. Many quaternary ammonium compounds have been synthesized that are not only antibacterial, but also possess antifungal, antiviral and anti-matrix metalloproteinase capabilities.
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  • Effect of a novel quaternary ammonium silane on dentin protease activities
    ELSEVIER
    The newly developed antibacterial quaternary ammonium silane increases the resistance of dentin collagen to degradation by inhibiting endogenous matrix metalloproteinases and cysteine cathepsins. The quaternary ammonium silane cavity disinfectant is promising for use as a protease inhibitor to improve durability of resin-dentin bonds.
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  • Quaternary Ammonium Methacryloxy Silicate containing Acrylic Resin
    ClinicalTrials.gov
    Biofilm killing efficacy - In vivo antimicrobial efficacy of QAMS-containing PMMA disks placed in orthodontic retainers that are worn by subjects to create multi-species biofilms.
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  • Anti-herpes viral effects of a novel broad range anti-microbial quaternary ammonium silane, K21
    ELSEVIER
    In order to design a QAC with enhanced antimicrobial properties, we developed ethoxylated version of the QAC, called K21, which was tested effective against Porphyromonas gingivalis and Enterococcus faecalis (Meghil et al., 2015). With an intention of using K21 in dental materials, we tested efficacy of K21 against some of the human herpes viruses including HSV-1, HHV-6A, HHV- 6B and HHV-7 that reside in the human oral cavities and are shed in the saliva to induce infection.
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  • Antimicrobial activity of a quaternary ammonium methacryloxy silicate-containing acrylic resin: a randomised clinical trial
    Research
    The QAMS-copolymerized acrylic resin demonstrated contact-killing properties against single-species biofilms in previous in vitro studies and has received US FDA 510(K) clearance.
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  • Antimicrobial Compound K21 inhibits replication of enveloped & non-enveloped DNA & RNA Viruses
    fiteBac
    The data generated in our studies showed that K-21 is a potent antiviral and after safety studies can be useful for human trials to prevent various antimicrobial infections. K-21 can be useful in the form of germicidal spray, disinfectant hand-gel and aerosol.
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  • Antimycobacterial Activity of KHG fiteBac Test Substances K18 & K21 Using MTB Cultures
    Research
    Author / Source: James Stoops University of Texas Health Science Center at Houston File Security:    Public Access Download Document Download (PDF, 134KB) View Full List of Research Papers
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  • Anti-viral Activity of Quaternary Ammonium Silane (K21) Against HHV-6A and HHV-7
    fiteBac
    Author / Source: KHG fiteBac File Security:    Public Access Download Document Download (PDF, 1.61MB) View Full List of Research Papers
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  • Effect of K18 and k21with Adhesives on Bond Strenth
    fiteBac
    Author / Source: fiteBac File Security:    Public Access Download Document Download (PDF, 139KB) View Full List of Research Papers
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  • Antimicrobial activity of a quaternary ammonium methacryloxy silicate containing acrylic resin: a randomised clinical trial
    fiteBac
    Author / Source: FrankTay - KHG fiteBac® File Security:    Public Access Download DocumentSupplemental Research: Download DocumentDue to the graphical content, this file is too large to display in the browser window. Please click download to view this document. View Full List of Research Papers
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  • Quaternary Ammonium Methacryloxy Silicate Containing Acrylic Resin
    ClinicalTrials.gov
    Author / Source: FrankTay - KHG fiteBac® File Security:    Public Access Download Document Download (PDF, 90KB) View Full List of Research Papers
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  • Prebond Results with Methoxy - Powerpoint
    fiteBac
    Author / Source: Frank Tay - KHG fiteBac® File Security:    Public Access Download Document View Full List of Research Papers
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  • Broad Spectrum Antimicrobial Quaternary Ammonium Silane (K21) Effective Against HSV-1 and HHV-6
    fiteBac
    Author / Source: KHG fiteBac® File Security:    Public Access Download Document Download (PDF, 63KB) View Full List of Research Papers
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  • Report: Antimycobacterial Activity of KHG fiteBac Test Substances K18 & K21 Using MTB Cultures
    Research
    Author / Source: University of Texas / UT Health File Security:    Public Access Download Document Download (PDF, 127KB) View Full List of Research Papers
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  • K21 Poster Presented at the 3rd Antivirals Conference Amsterdam
    fiteBac
    Author / Source: KHG fiteBac® File Security:    Public Access Download Document Download (PDF, 2.9MB) View Full List of Research Papers
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  • Novel antiviral compound K18 effective against HSV-1
    fiteBac
    Author / Source: KHG fiteBac® File Security:    Public Access Download Document Download (PDF, 209KB) View Full List of Research Papers
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  • Novel antiviral compound K21 effective against HSV-1
    fiteBac
    Author / Source: KHG fiteBac® File Security:    Public Access Download Document Download (PDF, 208KB) View Full List of Research Papers
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  • Effect of QAM 1-1-3 Additions (3%) on selected physical properties of a commercial, light-cured resin cement
    Georgia Health Services University
    Author / Source: Georgia Health Services University File Security:    Public Access Download DocumentFile Size Exceeds Document Preview Capabilities - Please Download Download (PDF, 33.13MB) View Full List of Research Papers
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  • One-pot synthesis of antibacterial monomers with dual biocidal modes
    ELSEVIER
    Author / Source: ELSEVIER SciVerse Science Direct File Security:    Public Access Download Document Download (PDF, 4.18MB) View Full List of Research Papers
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  • An ORMOSIL-Containing Orthodontic Acrylic Resin with Concomitant Improvements in Antimicrobial and Fracture Toughness Properties
    PLoS ONE
    Author / Source: PLoS ONE www.plosone.org File Security:    Public Access Download Document Download (PDF, 4.07MB) View Full List of Research Papers
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  • Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential
    ELSEVIER
    Author / Source: ELSEVIER SciVerse Science Direct File Security:    Public Access Download Document Download (PDF, 2.76MB) View Full List of Research Papers
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  • Investigation of quaternary ammonium silane-coated sand filter for the removal of bacteria and viruses from drinking water
    Journal of Applied Microbiology
    Author / Source: Journal of Applied Microbiology ISSN 1364-5072 File Security:    Public Access Download Document Download (PDF, 271KB) View Full List of Research Papers
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  • Synthesis of antimicrobial silsesquioxane–silica hybrids by hydrolytic co-condensation of alkoxysilanes
    Polymer Chemistry
    Author / Source: Polymer Chemistry, 2014, 5, 454 File Security:    Public Access Download Document Download (PDF, 1.11MB) View Full List of Research Papers
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  • Removal and Inactivation of Viruses by a Surface-Bonded Quaternary Ammonium Chloride
    Research
    Author / Source: Department of Chemical Engineering University of Michigan File Security:    Public Access Download Document Download (PDF, 4.1MB) View Full List of Research Papers
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  • In Vitro Evaluation of Antibacterial Effect of AH Plus Incorporated with Quaternary Ammonium Epoxy Silicate against Enterococcus faecalis
    Journal of Endodontics
    Author / Source: AH Plus and QAES File Security:    Public Access Download Document Download (PDF, 1.1MB) View Full List of Research Papers
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  • Virucidal Efficacy of Four New Disinfectants
    American Animal Hospital Assoc.
    Author / Source: Journal of the American Animal Hospital Association File Security:    Public Access Download Document Download (PDF, 111KB) View Full List of Research Papers
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  • Effects of Chlorine, Iodine, and Quaternary Ammonium Compound Disenfectants on Several Exotic Disease Viruses
    Japanese Society of Veterinary Science
    Author / Source: Japanese Society of Veterinary Science File Security:    Public Access Download Document Download (PDF, 2.75MB) View Full List of Research Papers
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  • Interaction of Infectious Viral Particles with a Quaternary Ammonium Chloride (QAC) Surface
    Research
    Author / Source: Biotechnology and Bioengeneering, VOL. 34, File Security:    Public Access Download Document Download (PDF, 1.34MB) View Full List of Research Papers
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  • Effect of water-aging on the antimicrobial activities of an ORMOSIL-containing orthodontic acrylic resin
    ELSEVIER
    Author / Source: ELSEVIER SciVerse Science Direct File Security:    Public Access Download Document Download (PDF, 3.09MB) View Full List of Research Papers
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  • Reregistration Eligibility Decision for Trimethoxysilyl Quaternary Ammonium Chloride Compounds
    Research
    Author / Source: US Environmental Protection Agency File Security:    Public Access Download Document Download (PDF, 670KB) View Full List of Research Papers
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  • Different Virucidal Activities of Hyperbranched Quaternary Ammonium Coatings on Poliovirus and Influenza Virus
    American Society for Microbiology
    Author / Source: American Society for Microbiology File Security:    Public Access Download Document Download (PDF, 217KB) View Full List of Research Papers
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  • Contact Angle Measurement of QAM Added Choice 2 Resin Cement
    Georgia Health Services University
    Author / Source: Georgia Health Sciences University File Security:    Public Access Download Document Download (PDF, 6.14MB) View Full List of Research Papers
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