Optimizing resin-dentin bond stability using a bioactive adhesive with concomitant antibacterial properties and anti-proteolytic activities

Secondary caries and hybrid layer degradation are two major challenges encountered in long-term resindentin
bond stability. As a link between resin and dentin, adhesives that possess both antimicrobial and
anti-proteolytic activities are in demand for eliminating bacteria-induced secondary caries and preventing
hybrid layers from degradation. In the present study, a new quaternary ammonium methacryloxy
silane (QAMS) prepared from sol-gel chemistry was incorporated into experimental adhesives to examine
their antimicrobial effect and anti-proteolytic potential.

Use of whole genome deep sequencing to define emerging minority variants in virus envelope genes in herpesvirus treated with novel antimicrobial K21

New antivirals are required to prevent rising antimicrobial resistance from replication inhibitors. The aim
of this study was to analyse the range of emerging mutations in herpesvirus by whole genome deep sequencing. We tested human herpesvirus 6 treatment with novel antiviral K21, where evidence indicated distinct effects on virus envelope proteins.

Effect of a novel quaternary ammonium silane on dentin protease activities

The newly developed antibacterial quaternary ammonium silane increases the
resistance of dentin collagen to degradation by inhibiting endogenous matrix metalloproteinases and
cysteine cathepsins. The quaternary ammonium silane cavity disinfectant is promising for use as a
protease inhibitor to improve durability of resin-dentin bonds.

Anti-herpes viral effects of a novel broad range anti-microbial quaternary ammonium silane, K21

In order to design a QAC with enhanced antimicrobial
properties, we developed ethoxylated version of the QAC, called
K21, which was tested effective against Porphyromonas gingivalis

and Enterococcus faecalis (Meghil et al., 2015). With an intention of
using K21 in dental materials, we tested efficacy of K21 against
some of the human herpes viruses including HSV-1, HHV-6A, HHV-
6B and HHV-7 that reside in the human oral cavities and are shed in
the saliva to induce infection.