Recent publications on covalently bound ORMOSIL-containing orthodontic acrylic (Quaternary Ammonium Methacrylate Silicate – QAMS) demonstrated . . .
Significant fracture toughness increase
Ability to work against wide range of organisms
Non-leaching
Long-lasting (abstracts #662 and 663) (3-mos)
A quaternary ammonium silane antimicrobial triggers bacterial membrane and bioflm destruction
Recent publications on covalently bound ORMOSIL-containing orthodontic acrylic (Quaternary Ammonium Methacrylate Silicate – QAMS) demonstrated . . .
Significant fracture toughness increase
Ability to work against wide range of organisms
Non-leaching
Long-lasting (abstracts #662 and 663) (3-mos)
Quaternary ammonium silane, calcium and phosphorus-loaded PLGA submicron particles against Enterococcus faecalis infection of teeth: An in vitro and in vivo study
Recent publications on covalently bound ORMOSIL-containing orthodontic acrylic (Quaternary Ammonium Methacrylate Silicate – QAMS) demonstrated . . .
Significant fracture toughness increase
Ability to work against wide range of organisms
Non-leaching
Long-lasting (abstracts #662 and 663) (3-mos)
Effect of a Novel Quaternary Ammonium Silane cavity Disinfectant on Cariogenic Biofilm Formation
Recent publications on covalently bound ORMOSIL-containing orthodontic acrylic (Quaternary Ammonium Methacrylate Silicate – QAMS) demonstrated . . .
Significant fracture toughness increase
Ability to work against wide range of organisms
Non-leaching
Long-lasting (abstracts #662 and 663) (3-mos)
Transdentinal Cytotoxicity and Macrophagephenotype of a Novel Quaternary Ammoniumsilane Cavity Disinfectant.
Recent publications on covalently bound ORMOSIL-containing orthodontic acrylic (Quaternary Ammonium Methacrylate Silicate – QAMS) demonstrated . . .
Significant fracture toughness increase
Ability to work against wide range of organisms
Non-leaching
Long-lasting (abstracts #662 and 663) (3-mos)
Physical property effect of antimicrobial additive in light cured resin cement
Recent publications on covalently bound ORMOSIL-containing orthodontic acrylic (Quaternary Ammonium Methacrylate Silicate – QAMS) demonstrated . . .
Significant fracture toughness increase
Ability to work against wide range of organisms
Non-leaching
Long-lasting (abstracts #662 and 663) (3-mos)
Optimizing resin-dentin bond stability using a bioactive adhesive with concomitant antibacterial properties and anti-proteolytic activities
Secondary caries and hybrid layer degradation are two major challenges encountered in long-term resindentin
bond stability. As a link between resin and dentin, adhesives that possess both antimicrobial and
anti-proteolytic activities are in demand for eliminating bacteria-induced secondary caries and preventing
hybrid layers from degradation. In the present study, a new quaternary ammonium methacryloxy
silane (QAMS) prepared from sol-gel chemistry was incorporated into experimental adhesives to examine
their antimicrobial effect and anti-proteolytic potential.
Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant – ClinicalTrials.gov
New antivirals are required to prevent rising antimicrobial resistance from replication inhibitors. The aim
of this study was to analyse the range of emerging mutations in herpesvirus by whole genome deep sequencing. We tested human herpesvirus 6 treatment with novel antiviral K21, where evidence indicated distinct effects on virus envelope proteins.
Use of whole genome deep sequencing to define emerging minority variants in virus envelope genes in herpesvirus treated with novel antimicrobial K21
New antivirals are required to prevent rising antimicrobial resistance from replication inhibitors. The aim
of this study was to analyse the range of emerging mutations in herpesvirus by whole genome deep sequencing. We tested human herpesvirus 6 treatment with novel antiviral K21, where evidence indicated distinct effects on virus envelope proteins.
Quaternary ammonium based biomedical materials: State-of-the-art toxicological aspects and antimicrobial resistance
Microbial infections affect humans worldwide. Many quaternary ammonium compounds have been synthesized that are not only antibacterial, but also possess antifungal, antiviral and anti-matrix metalloproteinase capabilities.
Effect of a novel quaternary ammonium silane on dentin protease activities
The newly developed antibacterial quaternary ammonium silane increases the
resistance of dentin collagen to degradation by inhibiting endogenous matrix metalloproteinases and
cysteine cathepsins. The quaternary ammonium silane cavity disinfectant is promising for use as a
protease inhibitor to improve durability of resin-dentin bonds.
Effect of a novel quaternary ammonium silane cavity disinfectant on durability of resin-dentine bond
The newly developed antibacterial quaternary ammonium silane increases the
resistance of dentin collagen to degradation by inhibiting endogenous matrix metalloproteinases and
cysteine cathepsins. The quaternary ammonium silane cavity disinfectant is promising for use as a
protease inhibitor to improve durability of resin-dentin bonds.
Anti-herpes viral effects of a novel broad range anti-microbial quaternary ammonium silane, K21
In order to design a QAC with enhanced antimicrobial
properties, we developed ethoxylated version of the QAC, called
K21, which was tested effective against Porphyromonas gingivalis
and Enterococcus faecalis (Meghil et al., 2015). With an intention of
using K21 in dental materials, we tested efficacy of K21 against
some of the human herpes viruses including HSV-1, HHV-6A, HHV-
6B and HHV-7 that reside in the human oral cavities and are shed in
the saliva to induce infection.
Antimicrobial activity of a quaternary ammonium methacryloxy silicate-containing acrylic resin: a randomised clinical trial
The QAMS-copolymerized acrylic resin demonstrated contact-killing properties against single-species biofilms in previous in vitro studies and has received US FDA 510(K) clearance.