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K21 Compound, a Potent Antifungal Agent: Implications for the Treatment of Fluconazole-Resistant HIV-Associated Candida SpeciesRecent publications on covalently bound ORMOSIL-containing orthodontic acrylic (Quaternary Ammonium Methacrylate Silicate – QAMS) demonstrated . . . Significant fracture toughness increase Ability to work against wide range of organisms Non-leaching Long-lasting (abstracts #662 and 663) (3-mos)
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A quaternary ammonium silane antimicrobial triggers bacterial membrane and bioflm destructionRecent publications on covalently bound ORMOSIL-containing orthodontic acrylic (Quaternary Ammonium Methacrylate Silicate – QAMS) demonstrated . . . Significant fracture toughness increase Ability to work against wide range of organisms Non-leaching Long-lasting (abstracts #662 and 663) (3-mos)
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Quaternary ammonium silane, calcium and phosphorus-loaded PLGA submicron particles against Enterococcus faecalis infection of teeth: An in vitro and in vivo studyRecent publications on covalently bound ORMOSIL-containing orthodontic acrylic (Quaternary Ammonium Methacrylate Silicate – QAMS) demonstrated . . . Significant fracture toughness increase Ability to work against wide range of organisms Non-leaching Long-lasting (abstracts #662 and 663) (3-mos)
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Effect of a Novel Quaternary Ammonium Silane cavity Disinfectant on Cariogenic Biofilm FormationRecent publications on covalently bound ORMOSIL-containing orthodontic acrylic (Quaternary Ammonium Methacrylate Silicate – QAMS) demonstrated . . . Significant fracture toughness increase Ability to work against wide range of organisms Non-leaching Long-lasting (abstracts #662 and 663) (3-mos)
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Transdentinal Cytotoxicity and Macrophagephenotype of a Novel Quaternary Ammoniumsilane Cavity Disinfectant.Recent publications on covalently bound ORMOSIL-containing orthodontic acrylic (Quaternary Ammonium Methacrylate Silicate – QAMS) demonstrated . . . Significant fracture toughness increase Ability to work against wide range of organisms Non-leaching Long-lasting (abstracts #662 and 663) (3-mos)
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Physical property effect of antimicrobial additive in light cured resin cementRecent publications on covalently bound ORMOSIL-containing orthodontic acrylic (Quaternary Ammonium Methacrylate Silicate – QAMS) demonstrated . . . Significant fracture toughness increase Ability to work against wide range of organisms Non-leaching Long-lasting (abstracts #662 and 663) (3-mos)
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Optimizing resin-dentin bond stability using a bioactive adhesive with concomitant antibacterial properties and anti-proteolytic activitiesSecondary caries and hybrid layer degradation are two major challenges encountered in long-term resindentin bond stability. As a link between resin and dentin, adhesives that possess both antimicrobial and anti-proteolytic activities are in demand for eliminating bacteria-induced secondary caries and preventing hybrid layers from degradation. In the present study, a new quaternary ammonium methacryloxy silane (QAMS) prepared from sol-gel chemistry was incorporated into experimental adhesives to examine their antimicrobial effect and anti-proteolytic potential.
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Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant - ClinicalTrials.govNew antivirals are required to prevent rising antimicrobial resistance from replication inhibitors. The aim of this study was to analyse the range of emerging mutations in herpesvirus by whole genome deep sequencing. We tested human herpesvirus 6 treatment with novel antiviral K21, where evidence indicated distinct effects on virus envelope proteins.
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Use of whole genome deep sequencing to define emerging minority variants in virus envelope genes in herpesvirus treated with novel antimicrobial K21New antivirals are required to prevent rising antimicrobial resistance from replication inhibitors. The aim of this study was to analyse the range of emerging mutations in herpesvirus by whole genome deep sequencing. We tested human herpesvirus 6 treatment with novel antiviral K21, where evidence indicated distinct effects on virus envelope proteins.
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Quaternary ammonium based biomedical materials: State-of-the-art toxicological aspects and antimicrobial resistanceMicrobial infections affect humans worldwide. Many quaternary ammonium compounds have been synthesized that are not only antibacterial, but also possess antifungal, antiviral and anti-matrix metalloproteinase capabilities.
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Effect of a novel quaternary ammonium silane on dentin protease activitiesThe newly developed antibacterial quaternary ammonium silane increases the resistance of dentin collagen to degradation by inhibiting endogenous matrix metalloproteinases and cysteine cathepsins. The quaternary ammonium silane cavity disinfectant is promising for use as a protease inhibitor to improve durability of resin-dentin bonds.
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Effect of a novel quaternary ammonium silane cavity disinfectant on durability of resin-dentine bondThe newly developed antibacterial quaternary ammonium silane increases the resistance of dentin collagen to degradation by inhibiting endogenous matrix metalloproteinases and cysteine cathepsins. The quaternary ammonium silane cavity disinfectant is promising for use as a protease inhibitor to improve durability of resin-dentin bonds.
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Anti-herpes viral effects of a novel broad range anti-microbial quaternary ammonium silane, K21In order to design a QAC with enhanced antimicrobial properties, we developed ethoxylated version of the QAC, called K21, which was tested effective against Porphyromonas gingivalis and Enterococcus faecalis (Meghil et al., 2015). With an intention of using K21 in dental materials, we tested efficacy of K21 against some of the human herpes viruses including HSV-1, HHV-6A, HHV- 6B and HHV-7 that reside in the human oral cavities and are shed in the saliva to induce infection.
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Antimicrobial activity of a quaternary ammonium methacryloxy silicate-containing acrylic resin: a randomised clinical trialThe QAMS-copolymerized acrylic resin demonstrated contact-killing properties against single-species biofilms in previous in vitro studies and has received US FDA 510(K) clearance.
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Antimicrobial Compound K21 inhibits replication of enveloped & non-enveloped DNA & RNA VirusesThe data generated in our studies showed that K-21 is a potent antiviral and after safety studies can be useful for human trials to prevent various antimicrobial infections. K-21 can be useful in the form of germicidal spray, disinfectant hand-gel and aerosol.
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Anti-viral Activity of Quaternary Ammonium Silane (K21) Against HHV-6A and HHV-7Author / Source: KHG fiteBac File Security: Public Access Download Document Download (PDF, 1.61MB) View Full List of Research Papers
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Effect of K18 and k21with Adhesives on Bond StrenthAuthor / Source: fiteBac File Security: Public Access Download Document Download (PDF, 139KB) View Full List of Research Papers
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Antimicrobial activity of a quaternary ammonium methacryloxy silicate containing acrylic resin: a randomised clinical trialAuthor / Source: FrankTay - KHG fiteBac® File Security: Public Access Download DocumentSupplemental Research: Download DocumentDue to the graphical content, this file is too large to display in the browser window. Please click download to view this document. View Full List of Research Papers
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Quaternary Ammonium Methacryloxy Silicate Containing Acrylic ResinAuthor / Source: FrankTay - KHG fiteBac® File Security: Public Access Download Document Download (PDF, 90KB) View Full List of Research Papers
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Prebond Results with Methoxy - PowerpointAuthor / Source: Frank Tay - KHG fiteBac® File Security: Public Access Download Document View Full List of Research Papers
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Broad Spectrum Antimicrobial Quaternary Ammonium Silane (K21) Effective Against HSV-1 and HHV-6Author / Source: KHG fiteBac® File Security: Public Access Download Document Download (PDF, 63KB) View Full List of Research Papers
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K21 Poster Presented at the 3rd Antivirals Conference AmsterdamAuthor / Source: KHG fiteBac® File Security: Public Access Download Document Download (PDF, 2.9MB) View Full List of Research Papers
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Novel antiviral compound K18 effective against HSV-1Author / Source: KHG fiteBac® File Security: Public Access Download Document Download (PDF, 209KB) View Full List of Research Papers
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Novel antiviral compound K21 effective against HSV-1Author / Source: KHG fiteBac® File Security: Public Access Download Document Download (PDF, 208KB) View Full List of Research Papers
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One-pot synthesis of antibacterial monomers with dual biocidal modesAuthor / Source: ELSEVIER SciVerse Science Direct File Security: Public Access Download Document Download (PDF, 4.16MB) View Full List of Research Papers
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An ORMOSIL-Containing Orthodontic Acrylic Resin with Concomitant Improvements in Antimicrobial and Fracture Toughness PropertiesAuthor / Source: PLoS ONE www.plosone.org File Security: Public Access Download Document Download (PDF, 4.07MB) View Full List of Research Papers
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Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potentialAuthor / Source: ELSEVIER SciVerse Science Direct File Security: Public Access Download Document Download (PDF, 2.76MB) View Full List of Research Papers
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Synthesis of antimicrobial silsesquioxane–silica hybrids by hydrolytic co-condensation of alkoxysilanesAuthor / Source: Polymer Chemistry, 2014, 5, 454 File Security: Public Access Download Document Download (PDF, 1.11MB) View Full List of Research Papers
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In Vitro Evaluation of Antibacterial Effect of AH Plus Incorporated with Quaternary Ammonium Epoxy Silicate against Enterococcus faecalisAuthor / Source: AH Plus and QAES File Security: Public Access Download Document Download (PDF, 1.1MB) View Full List of Research Papers
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Effect of water-aging on the antimicrobial activities of an ORMOSIL-containing orthodontic acrylic resinAuthor / Source: ELSEVIER SciVerse Science Direct File Security: Public Access Download Document Download (PDF, 3.09MB) View Full List of Research Papers
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