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Physical property effect of antimicrobial additive in light cured resin cementRecent publications on covalently bound ORMOSIL-containing orthodontic acrylic (Quaternary Ammonium Methacrylate Silicate – QAMS) demonstrated . . . Significant fracture toughness increase Ability to work against wide range of organisms Non-leaching Long-lasting (abstracts #662 and 663) (3-mos)
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Optimizing resin-dentin bond stability using a bioactive adhesive with concomitant antibacterial properties and anti-proteolytic activitiesSecondary caries and hybrid layer degradation are two major challenges encountered in long-term resindentin bond stability. As a link between resin and dentin, adhesives that possess both antimicrobial and anti-proteolytic activities are in demand for eliminating bacteria-induced secondary caries and preventing hybrid layers from degradation. In the present study, a new quaternary ammonium methacryloxy silane (QAMS) prepared from sol-gel chemistry was incorporated into experimental adhesives to examine their antimicrobial effect and anti-proteolytic potential.
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Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant - ClinicalTrials.govNew antivirals are required to prevent rising antimicrobial resistance from replication inhibitors. The aim of this study was to analyse the range of emerging mutations in herpesvirus by whole genome deep sequencing. We tested human herpesvirus 6 treatment with novel antiviral K21, where evidence indicated distinct effects on virus envelope proteins.
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Use of whole genome deep sequencing to define emerging minority variants in virus envelope genes in herpesvirus treated with novel antimicrobial K21New antivirals are required to prevent rising antimicrobial resistance from replication inhibitors. The aim of this study was to analyse the range of emerging mutations in herpesvirus by whole genome deep sequencing. We tested human herpesvirus 6 treatment with novel antiviral K21, where evidence indicated distinct effects on virus envelope proteins.
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Quaternary ammonium based biomedical materials: State-of-the-art toxicological aspects and antimicrobial resistanceMicrobial infections affect humans worldwide. Many quaternary ammonium compounds have been synthesized that are not only antibacterial, but also possess antifungal, antiviral and anti-matrix metalloproteinase capabilities.
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Quaternary Ammonium Methacryloxy Silicate containing Acrylic ResinBiofilm killing efficacy - In vivo antimicrobial efficacy of QAMS-containing PMMA disks placed in orthodontic retainers that are worn by subjects to create multi-species biofilms.
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Anti-herpes viral effects of a novel broad range anti-microbial quaternary ammonium silane, K21In order to design a QAC with enhanced antimicrobial properties, we developed ethoxylated version of the QAC, called K21, which was tested effective against Porphyromonas gingivalis and Enterococcus faecalis (Meghil et al., 2015). With an intention of using K21 in dental materials, we tested efficacy of K21 against some of the human herpes viruses including HSV-1, HHV-6A, HHV- 6B and HHV-7 that reside in the human oral cavities and are shed in the saliva to induce infection.
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Antimicrobial activity of a quaternary ammonium methacryloxy silicate-containing acrylic resin: a randomised clinical trialThe QAMS-copolymerized acrylic resin demonstrated contact-killing properties against single-species biofilms in previous in vitro studies and has received US FDA 510(K) clearance.
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Antimicrobial Compound K21 inhibits replication of enveloped & non-enveloped DNA & RNA VirusesThe data generated in our studies showed that K-21 is a potent antiviral and after safety studies can be useful for human trials to prevent various antimicrobial infections. K-21 can be useful in the form of germicidal spray, disinfectant hand-gel and aerosol.
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Antimycobacterial Activity of KHG fiteBac Test Substances K18 & K21 Using MTB CulturesAuthor / Source: James Stoops University of Texas Health Science Center at Houston File Security: Public Access Download Document Download (PDF, 134KB) View Full List of Research Papers
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Anti-viral Activity of Quaternary Ammonium Silane (K21) Against HHV-6A and HHV-7Author / Source: KHG fiteBac File Security: Public Access Download Document Download (PDF, 1.61MB) View Full List of Research Papers
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Effect of K18 and k21with Adhesives on Bond StrenthAuthor / Source: fiteBac File Security: Public Access Download Document Download (PDF, 139KB) View Full List of Research Papers
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Antimicrobial activity of a quaternary ammonium methacryloxy silicate containing acrylic resin: a randomised clinical trialAuthor / Source: FrankTay - KHG fiteBac® File Security: Public Access Download DocumentSupplemental Research: Download DocumentDue to the graphical content, this file is too large to display in the browser window. Please click download to view this document. View Full List of Research Papers
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Quaternary Ammonium Methacryloxy Silicate Containing Acrylic ResinAuthor / Source: FrankTay - KHG fiteBac® File Security: Public Access Download Document Download (PDF, 90KB) View Full List of Research Papers
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Prebond Results with Methoxy - PowerpointAuthor / Source: Frank Tay - KHG fiteBac® File Security: Public Access Download Document View Full List of Research Papers
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Broad Spectrum Antimicrobial Quaternary Ammonium Silane (K21) Effective Against HSV-1 and HHV-6Author / Source: KHG fiteBac® File Security: Public Access Download Document Download (PDF, 63KB) View Full List of Research Papers
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Report: Antimycobacterial Activity of KHG fiteBac Test Substances K18 & K21 Using MTB CulturesAuthor / Source: University of Texas / UT Health File Security: Public Access Download Document Download (PDF, 127KB) View Full List of Research Papers
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K21 Poster Presented at the 3rd Antivirals Conference AmsterdamAuthor / Source: KHG fiteBac® File Security: Public Access Download Document Download (PDF, 2.9MB) View Full List of Research Papers
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Novel antiviral compound K18 effective against HSV-1Author / Source: KHG fiteBac® File Security: Public Access Download Document Download (PDF, 209KB) View Full List of Research Papers
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Novel antiviral compound K21 effective against HSV-1Author / Source: KHG fiteBac® File Security: Public Access Download Document Download (PDF, 208KB) View Full List of Research Papers
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Effect of QAM 1-1-3 Additions (3%) on selected physical properties of a commercial, light-cured resin cementAuthor / Source: Georgia Health Services University File Security: Public Access Download DocumentFile Size Exceeds Document Preview Capabilities - Please Download Download (PDF, 33.13MB) View Full List of Research Papers
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One-pot synthesis of antibacterial monomers with dual biocidal modesAuthor / Source: ELSEVIER SciVerse Science Direct File Security: Public Access Download Document Download (PDF, 4.16MB) View Full List of Research Papers
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An ORMOSIL-Containing Orthodontic Acrylic Resin with Concomitant Improvements in Antimicrobial and Fracture Toughness PropertiesAuthor / Source: PLoS ONE www.plosone.org File Security: Public Access Download Document Download (PDF, 4.07MB) View Full List of Research Papers
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Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potentialAuthor / Source: ELSEVIER SciVerse Science Direct File Security: Public Access Download Document Download (PDF, 2.76MB) View Full List of Research Papers
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Investigation of quaternary ammonium silane-coated sand filter for the removal of bacteria and viruses from drinking waterAuthor / Source: Journal of Applied Microbiology ISSN 1364-5072 File Security: Public Access Download Document Download (PDF, 271KB) View Full List of Research Papers
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Synthesis of antimicrobial silsesquioxane–silica hybrids by hydrolytic co-condensation of alkoxysilanesAuthor / Source: Polymer Chemistry, 2014, 5, 454 File Security: Public Access Download Document Download (PDF, 1.11MB) View Full List of Research Papers
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Removal and Inactivation of Viruses by a Surface-Bonded Quaternary Ammonium ChlorideAuthor / Source: Department of Chemical Engineering University of Michigan File Security: Public Access Download Document Download (PDF, 4.1MB) View Full List of Research Papers
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In Vitro Evaluation of Antibacterial Effect of AH Plus Incorporated with Quaternary Ammonium Epoxy Silicate against Enterococcus faecalisAuthor / Source: AH Plus and QAES File Security: Public Access Download Document Download (PDF, 1.1MB) View Full List of Research Papers
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Virucidal Efficacy of Four New DisinfectantsAuthor / Source: Journal of the American Animal Hospital Association File Security: Public Access Download Document Download (PDF, 111KB) View Full List of Research Papers
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Effects of Chlorine, Iodine, and Quaternary Ammonium Compound Disenfectants on Several Exotic Disease VirusesAuthor / Source: Japanese Society of Veterinary Science File Security: Public Access Download Document Download (PDF, 2.75MB) View Full List of Research Papers
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Interaction of Infectious Viral Particles with a Quaternary Ammonium Chloride (QAC) SurfaceAuthor / Source: Biotechnology and Bioengeneering, VOL. 34, File Security: Public Access Download Document Download (PDF, 1.34MB) View Full List of Research Papers
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Effect of water-aging on the antimicrobial activities of an ORMOSIL-containing orthodontic acrylic resinAuthor / Source: ELSEVIER SciVerse Science Direct File Security: Public Access Download Document Download (PDF, 3.09MB) View Full List of Research Papers
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Reregistration Eligibility Decision for Trimethoxysilyl Quaternary Ammonium Chloride CompoundsAuthor / Source: US Environmental Protection Agency File Security: Public Access Download Document Download (PDF, 670KB) View Full List of Research Papers
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Different Virucidal Activities of Hyperbranched Quaternary Ammonium Coatings on Poliovirus and Influenza VirusAuthor / Source: American Society for Microbiology File Security: Public Access Download Document Download (PDF, 217KB) View Full List of Research Papers
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Contact Angle Measurement of QAM Added Choice 2 Resin CementAuthor / Source: Georgia Health Sciences University File Security: Public Access Download Document Download (PDF, 6.14MB) View Full List of Research Papers
